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pentobarbital will lessen the level or effect of alfentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.pentobarbital will decrease the level or result of buprenorphine buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will decrease the extent or impact of ne